Charaf Benarafa Selected Research

Cathepsin G

1/2019	Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
11/2016	Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells.
1/2016	Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1.
8/2011	Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection.
10/2006	SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia.

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Charaf Benarafa Research Topics

Disease

11	Inflammation (Inflammations) 11/2019 - 03/2002
8	Infections 12/2020 - 08/2007
4	Pneumonia (Pneumonitis) 12/2013 - 05/2008
3	Emphysema 12/2020 - 01/2011
3	Neoplasms (Cancer) 11/2016 - 03/2002
2	COVID-19 01/2021 - 10/2020
2	Eosinophilia 01/2021 - 07/2002
2	Disease Progression 12/2020 - 12/2013
2	Peritonitis 12/2017 - 02/2014
2	Chronic Obstructive Pulmonary Disease (COPD) 03/2016 - 01/2011
2	Pseudomonas Infections 01/2011 - 08/2007
1	Pneumococcal Infections 12/2020
1	Dysbiosis 12/2020
1	Pulmonary Emphysema 12/2020
1	Colitis 11/2019
1	Neuroinflammatory Diseases 03/2019
1	Encephalomyelitis (Myeloencephalitis) 03/2019
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 03/2019
1	Necrosis 01/2019
1	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/2018
1	Hypereosinophilic Syndrome (Loeffler Endocarditis) 12/2016
1	Glioblastoma (Glioblastoma Multiforme) 11/2016
1	Eye Diseases (Eye Disease) 11/2016
1	Neutropenia 01/2016
1	Lung Injury 12/2012
1	Human Influenza (Influenza) 08/2011
1	Cystic Fibrosis (Mucoviscidosis) 01/2011
1	Sepsis (Septicemia) 01/2011
1	Arthritis (Polyarthritis) 01/2011
1	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy) 10/2010
1	Thrombocytopenia (Thrombopenia) 05/2008
1	Hemorrhage 05/2008
1	Anemia 05/2008
1	Bronchopulmonary Dysplasia 10/2006
1	Hyperglycemia 03/2004
1	Proteinuria 03/2004
1	Diabetic Nephropathies (Diabetic Nephropathy) 03/2004
1	Hyperlipidemias (Hyperlipidemia) 03/2004
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2004

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 10/2020 - 03/2004
5	Cathepsin GIBA 01/2019 - 10/2006
5	CytokinesIBA 03/2016 - 08/2007
4	SmokeIBA 12/2020 - 12/2013
4	Peptide Hydrolases (Proteases)FDA Link 11/2016 - 03/2002
3	Pancreatic Elastase (Elastase)IBA 12/2012 - 03/2004
3	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 12/2012 - 08/2007
3	SerpinsIBA 01/2011 - 03/2002
2	Glycoproteins (Glycoprotein)IBA 01/2021 - 05/2008
2	Serine Proteases (Serine Protease)IBA 11/2016 - 08/2011
2	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 12/2012 - 08/2007
2	ChemokinesIBA 08/2007 - 07/2002
1	AngiotensinsIBA 01/2021
1	Cell Surface ReceptorsIBA 01/2021
1	Interleukin-5 (Interleukin 5)IBA 01/2021
1	T2AAIBA 11/2019
1	Benzene (Benzole)IBA 11/2019
1	Sulfonic AcidsIBA 11/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2018
1	Annexin A1IBA 12/2017
1	Myeloblastin (Proteinase 3)IBA 12/2017
1	ZymosanIBA 12/2017
1	GTP Phosphohydrolases (GTPases)IBA 12/2016
1	Histocompatibility Antigens Class IIBA 11/2016
1	LactoferrinIBA 11/2016
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 03/2016
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 03/2016
1	2- aminoethyl- 3- O- sulfo- galactopyranosyl- (1- 3)- 2- acetamido- 2- deoxy- galactopyranosyl- (1- 4)- 3- O- sulfo- galactopyranosyl- (1- 4)- beta- D- glucopyranosideIBA 01/2016
1	Death-Associated Protein KinasesIBA 02/2014
1	Extracellular Matrix ProteinsIBA 12/2013
1	AlbuminsIBA 12/2012
1	Peroxidase (Myeloperoxidase)IBA 12/2012
1	Interleukin-6 (Interleukin 6)IBA 08/2011
1	EnzymesIBA 01/2011
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 10/2010
1	Serine (L-Serine)FDA Link 05/2010
1	Threonine (L-Threonine)FDA Link 05/2010
1	PhosphoproteinsIBA 05/2010
1	adhesion receptorIBA 05/2008
1	EndotoxinsIBA 05/2008
1	DiglyceridesIBA 05/2008
1	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 05/2008
1	CalciumIBA 05/2008
1	Leukocyte Elastase (Neutrophil Elastase)IBA 10/2006
1	ElastinIBA 03/2004
1	ProteomeIBA 03/2004

Therapy/Procedure

2	Therapeutics 02/2014 - 12/2012
1	Ligation 12/2017
1	Punctures 12/2017